Unconcentrated CSF and diluted serum are electrophoresed by isoelectric focusing. Dr. Clardy has received personal compensation for serving as an employee of Veterans Health Administration (VHA). BMJ Case Rep. 2020 May 27;13(5):e234316. The presence of OCBs can indicate inflammation in the CNS. You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid Unauthorized use of these marks is strictly prohibited. Oligoclonal Bands CSF is used in the diagnosis of multiple sclerosis (MS) by identifying increased intrathecal IgG synthesis qualitatively (oligoclonal bands). CSF is used in the diagnosis of multiple sclerosis (MS) by identifying increased intrathecal IgG synthesis qualitatively (oligoclonal bands). To determine the diagnostic significance of serum OCBs 146 patients with serum OCBs were identified among 1874 patients with suspected neurological disorders (7.6%). A test that reveals elevated levels of OCBs could indicate MS. A person does not need to do much to prepare for the test itself. Increased intrathecal Ig synthesis may occur in other inflammatory CSF diseases and, therefore this assay is not specific for MS. CSF Oligoclonal Bands Interpretation: <2 bands. What Are the Risks Involved With a CSF Oligoclonal Banding Test? Finally, intrathecal humoral immune response can also occur, although rarely, in patients with peripheral neuropathies, particularly in those of inflammatory origin, as a possible consequence of blood-spinal nerve root barrier (BSNRB) damage. If a person receives a diagnosis of MS, they can find resources and support from the following organizations: OCBs appear in the CSF of the vast majority of people living with MS. Oligoclonal band investigations requires both serum and cerebral spinal fluid (CSF). Doctors can use this screen to help them diagnose MS. They will clean the skin and numb the area using a local anesthetic. Heres what you need to know about it. 2023 Healthline Media UK Ltd, Brighton, UK. 2023 Laboratory Corporation of America Holdings. government site. Two types of antibodies are detected in the Western blot test. Similarly, if a test comes back negative but a person is experiencing symptoms, additional tests may be necessary to confirm what is causing the symptoms. For assistance, contact. 1. Oligoclonal Bands - UpToDate and apply to letter. Subacute Cognitive Impairment in Individuals With Mild and Moderate COVID-19: A Case Series. OLIGS - Overview: Oligoclonal Banding, Serum The institution of Dr. Paz Soldan has received research support from National Institutes of Health. Dr. Rose has received intellectual property interests from a discovery or technology relating to health care. You can learn more about how we ensure our content is accurate and current by reading our. Your doctor will read them and discuss the next steps. OMG, you are so describing me. Have you found anything out yet? I've been dealing with this now for 2 years with no answers and countless tests. Make certain to include both prescription and over-the-counter medicines. CSF is the clear fluid that flows in the space The doctor or nurse will then perform the following steps: Lab technicians will then analyze the CSF sample for OCBs. Oligoclonal bands and antibody responses in multiple sclerosis. It causes periods of worsening symptoms and periods of remission. (Keir G, Luxton RW, Thompson EJ: Isoelectric focusing of cerebrospinal fluid immunoglobulins G: an annotated update. Typical example: MS. -, Ann Neurol. The diagnostic value of IgG index versus oligoclonal bands in cerebrospinal fluid of patients with multiple sclerosis. A doctor may use a CSF oligoclonal banding test to help confirm MS, but they will also need to consider other diagnostic criteria. Matched or Unique Cerebrospinal Fluid Oligoclonal Bands: Design/Methods: Retrospective chart review of patients seen at University of Utah Health who had oligoclonal band analysis performed at ARUP Laboratories (Salt Lake City, UT) between January 1, 2015 and September 24, 2020. Adv Clin Chem. Routine CSF examination includes measuring oligoclonal bands (OCB) status, IgG index, albumin ratio, and cell counts. Would you like email updates of new search results? Can diet help improve depression symptoms? Some doctors may perform a lumbar puncture using medical imaging for guidance, such as an ultrasound or interventional radiology. Dr. Greenlee has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Wheeler, Trigg, O'Donnell, LLP. Lumbar puncture (spinal tap), Oligoclonal banding, serum, and spinal fluid. The presence of multiple bands indicates that something is wrong. Dr. Greenlee has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Sommers Schwartz. A local anaesthetic is used for the short procedure. Unknown radiating nerve pain in legs, what could it be? The institution of Dr. Peterson has received research support from Kronus. Management of Carta S, Cobo Calvo , Armangu T, Saiz A, Lechner C, Rostsy K, Breu M, Baumann M, Hftberger R, Ayzenberg I, Schwake C, Sepulveda M, Martnez-Hernndez E, Oliv-Cirera G, Arrambide G, Tintor M, Bernard-Valnet R, Du Pasquier R, Brilot F, Ramanathan S, Schanda K, Gajofatto A, Ferrari S, Sechi E, Flanagan EP, Pittock SJ, Redenbaugh V, Reindl M, Marignier R, Mariotto S. Neurology. However, technical issues including blot, staining, and IEF reproducibility as well as operator-dependent pattern interpretations decrease reproducibility, causing misinterpretations of results, with significant diagnostic implications. A doctor may use a CSF oligoclonal banding test to help confirm a diagnosis of MS. While OCGB negative patients are unlikely to develop clinically definite (CD) MS, OCGB positivity may lead to an erroneous diagnosis in During the procedure, a person will lie on their side with their legs pulled up toward their chin and their chin tucked in. The most frequent coexisting systemic autoimmune diseases included hypothyroidism, systemic lupus erythematosus, and sarcoidosis. Patients with matched plus unique oligoclonal bands were more likely to have an inflammatory neurologic disease. If your work is strenuous and might involve your back, tell your doctor. 2022 Oct 23;12(11):2571. doi: 10.3390/diagnostics12112571. Unconcentrated CSF and diluted serum are electrophoresed by isoelectric focusing. CSF oligoclonal banding is a test ordered by physicians when serious health concerns related to your central nervous system arise. Am J Clin Pathol. An official website of the United States government. WebIn order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. These tests include kappa free light chains in the cerebrospinal fluid (CSF) and CSF oligoclonal band (OCB) detection. Approach to the patient with neurologic disease. Search for other works by this author on: Multiple cerebrospinal fluid bands: multiple sclerosis? I also have numbness in my left thumb and left toes (occasionally on the right too) and twitches in my legs. NOTE: The first author must also be the corresponding author of the comment. (n.d.) Retrieved from. In particular, cerebrospinal fluid (CSF)-restricted OCBs represent WebThe oligoclonal band (OCB) assay requires paired cerebrospinal fluid (CSF) and serum samples. Your role and/or occupation, e.g. 2022 Sep;59(6):391-404. doi: 10.1080/10408363.2022.2039591. Both serum and spinal fluid are required. The presence of more than one band is an indicator of illness. Neurology. The most common way to attain a sample is through a lumbar puncture, also CSF is the clear fluid that is present around the spinal cord and the brain. Ann Clin Biochem. However, medical risks exist, including: People usually have discomfort during and shortly after the test. Bookshelf MS is a disease that affects the CNS, which consists of the brain and spinal cord. Isoelectric focusing (IEF) on agarose gels followed by immunoblotting is the technique recommended for OCB detection, analyzing paired undiluted CSF and serum samples. The LOINC codes are copyright 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Oligoclonal Diagnosis of multiple sclerosis; especially useful in patients with equivocal clinical presentation and radiological findings, Isoelectric Focusing (IEF) with IgG Immunoblot Detection. The institution of Dr. Paz Soldan has received research support from Western Institute for Biomedical Research. The oligoclonal band pattern is blurred when a concomitant inflammatory response causes increased protein leakage of plasma proteins into the CSF. Absorbing shocks to your central nervous system, Circulating nutrients through your bloodstream, Sending messages to different parts of the brain, Tingly shock-like feelings from particular neck movements, Systemic lupus erythematosus, which is an autoimmune disease that causes widespread inflammation in your body, Human immunodeficiency virus (HIV) infection, which creates complications in your central nervous system, Stroke, which can result in permanent neural damage to the bodys communication with the central nervous system, Discomfort and pain at the injection site. 19952023 Mayo Foundation for Medical Education and Research. WebWhen the oligoclonal band assay detects 2 or more unique IgG bands in the cerebrospinal fluid (CSF), the result is positive. After a few moments, it will begin working. Serum and CSF Biomarkers Predict Active Early Cognitive Decline Rather Than Established Cognitive Impairment at the Moment of RRMS Diagnosis. 8600 Rockville Pike This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. CSF is the clear fluid that flows in the space around the spinal (Exception: original author replies can include all original authors of the article). (2014, December 6). Detection of Oligoclonal Ig Bands: Clinical Significance and Trends in Methodological Improvement. Abstracts of Presentations at the Association of Clinical Scientists 143. Your organization or institution (if applicable), e.g. His paired cerebrospinal fluid (CSF) and serum samples were sent to the clinical biochemistry laboratory for oligoclonal band analysis by CSF isoelectric focusing and IgG immunofixation (Fig. A normal result is no bands or just one band. By using this Site you agree to the following, By using this Site you agree to the following, Matching oligoclonal bands in CSF and serum, lack of information from neurologist , seeking second opinion. Elsevier; 2015:chap 18). Increased IgG production by the central nervous system is not specific for multiple sclerosis, but is an indication of chronic neural inflammation. Lisa Johnson has nothing to disclose. Oligoclonal bands in CSF have been reported in cases of neurosyphilis, acute bacterial or viral meningitis, progressive multifocal leukoencephalopathy, subacute sclerosing panencephalitis, progressive rubella panencephalitis, polyneuritis, optic neuritis, trypanosomiasis, and other infectious or autoimmune diseases. Neurology: Neuroimmunology & Neuroinflammation. Fortini AS, Sanders EL, Weinshenker BG, Katzmann JA. PMC The diagnostic process will also involve the doctor: If elevated OCB levels are present but a person does not fit the criteria for MS, a doctor will likely continue to search for the underlying cause. Disclaimer. CSF Oligoclonal Bands Dr. Clardy has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurology/AAN Publications. doi: 10.1371/journal.pone.0280864. (Press Enter or Space to Go to Landing Page or Press Down to expand Menu), Federally Qualified Health Centers (FQHCs), Combatting Modern Slavery and Human Trafficking Statement. In this special Missouri Medicine report, doctors examine advances in diagnosis and treatment of this devastating and costly neurodegenerative disease. IgG index We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Background: One means by which a diagnosis of autoimmune central nervous system disease is supported is via identification of unique oligoclonal bands in the cerebrospinal fluid. Autoimmune disorders. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. The https:// ensures that you are connecting to the EJIFCC. A. Have you found anything out yet? Detection of oligoclonal bands in patients with neurologic diseases: comparison between agarose gel-, immunofixation- and isoelectric-focusing electrophoresis. They also include facial numbness. 5 Less has been reported on the other patterns and their relevance in the wider range of CNS disorders. Theyll ask you to turn on your side and expose your back. Your last, or family, name, e.g. These bands in the CSF pattern are produced by a limited number of Corrective measures and identification of specialized laboratories with expertise in the field are fundamental to applying this useful technique in clinical practice. Could a little jolt of electricity to the outside of your head improve your brain function? doi: 10.1212/WNL.0000000000201662. Oligoclonal immunoglobulin G (IgG) bands (OCBs) are a useful diagnostic tool to detect a central humoral response. What should I do? Dr. Clardy has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ExpertConnect. Get a step-by-step look, CSF cell count and differential are measured during cerebrospinal fluid analysis. Matching oligoclonal bands in CSF and serum - MedHelp A persons healthcare team should make them aware of any additional steps they should take to prepare for the test. Discover some of the causes of dizziness and how to treat it. The institution of Dr. Rose has received research support from Guthy Jackson Charitable Foundation. In this case, further tests will be necessary to determine the cause of any disease. All Rights Reserved. Tests that show an elevated level of OCBs indicate that a person might be living with MS. 'Orthopedic Surgeon'. The reason for this is that the presence of OCBs can also indicate other conditions that cause inflammation in the CNS. Author Contributions:All authors confirmed they have contributed to the intellectual content of this paper and have met the following 3 requirements: (a) significant contributions to the conception and design, acquisition of data, or analysis and interpretation of data; (b) drafting or revising the article for intellectual content; and (c) final approval of the published article. Oligoclonal Bands The most common way to attain a sample is through a lumbar puncture, also known as a spinal tap., Spinal taps can be unnerving or uncomfortable, but the procedure is fairly simple. Anecdotal reports are surfacing that some people are developing tinnitus days after receiving one of the COVID vaccines. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements. Dr. Greenlee has received publishing royalties from a publication relating to health care. 2018 Feb;17(2):162-173, 4. 1994;57:897-902, 2. My neurologist says I should start experimenting with some medicines to see if any would help the dizziness. Because of this, oftentimes an extensive workup for mimickers is undertaken. Labs & Appointments Toggle Labs & Appointments, Billing & Insurance Toggle Billing & Insurance, Diseases & Conditions Toggle Diseases & Conditions, OnDemand Testing Toggle OnDemand Testing, Testing by Disease & Condition Toggle Testing by Disease & Condition, Testing & Services For Toggle Testing & Services For, Hospitals & Physician Systems Toggle Hospitals & Physician Systems, Managed Care Health Plans Toggle Managed Care Health Plans, Lab Data Integrations & Tools Toggle Lab Data Integrations & Tools, Employee Wellness & Testing Toggle Employee Wellness & Testing, Government & Education Toggle Government & Education, Therapeutic Indications Toggle Therapeutic Indications, Development Phase Toggle Development Phase, Compounds & Molecules Toggle Compounds & Molecules. This helps your physician identify the reason for any inflammation that may be present in your central nervous system., If there is a presence of oligoclonal bands of protein, multiple sclerosis is sometimes suspected as the cause. However, testing for OCB levels alone is not enough to diagnose MS. Unable to load your collection due to an error, Unable to load your delegates due to an error. Federal government websites often end in .gov or .mil. I am 44 and female. Last medically reviewed on June 15, 2016, A cerebrospinal fluid (CSF) test can be used to diagnose many conditions, from neurological disorders to infectious diseases. Multiple sclerosis (MS) is a progressive condition that affects the central nervous system and the brain. Diagnosis of multiple sclerosis; especially useful in patients with, Clients without access to Test Prices can contact, Prospective clients should contact their Regional Manager. My symptoms are The presence of 2 or more unique CSF oligoclonal bands was reintroduced as one of the diagnostic criteria for MS in the 2017 revised McDonald criteria. Dr. Poon has nothing to disclose. Saadeh R, Pittock S, Bryant S, et al: CSF kappa free light chains as a potential quantitative alternative to oligoclonal bands in multiple sclerosis. The detection of increased intrathecal immunoglobulin synthesis is the basis for current diagnostic laboratory tests for MS. These findings, however, are not specific for MS as CSF-specific IgG synthesis may also be found in patients with other neurologic diseases including infectious, inflammatory, cerebrovascular, and paraneoplastic disorders. Dizziness, light headed for 4 weeks. Centrifuge and aliquot serum within 2 hours of collection. In particular, cerebrospinal fluid (CSF)-restricted OCBs represent a hallmark of multiple sclerosis (MS), where they can be detected in > 90% of cases and support its diagnosis, although a specific causative agent inducing B cell activation has not yet been identified. WebCSF oligoclonal bands . What is the differential diagnosis for multiple bands in CSF with some accompanying bands in serum? Dr. Clardy has received personal compensation for serving as an employee of University of Utah Health. 7th ed. The following steps take place during a lumber puncture: You can expect to rest for an hour or two after your test. O'S-ci + *, only" (symbolised in the figure by a *); 3) patientswithatleast onecloneinserumandat least one clone unique to CSF, have both intrathecal andsystemic Scientists use genetic rewiring to increase lifespan of cells, Beyond amyloid and tau: New targets in developing dementia treatments, Napping longer than 30 minutes linked to higher risk of obesity and high blood pressure, Activity 'snacks' could lower blood sugar, complication risk in type 1 diabetes, In Conversation: Investigating the power of music for dementia, A comparison of systemic sclerosis and multiple sclerosis, Multiple sclerosis: 5 things to know about MS, Relapsing-remitting multiple sclerosis (MS), What to know about late onset multiple sclerosis, at least two areas of damage to, or lesions in, the brain or spinal cord, evidence that the damage occurred at different times, evidence that another disease has not caused the damage to the CNS. WebOligoclonal bands (OCBs) are bands of immunoglobulins that are seen when a patients blood serum, or cerebrospinal fluid (CSF) is analyzed. Oligoclonal band - Wikipedia FOIA 2018;56:1071-1080, 5. Epub 2022 Mar 11. Oligoclonal bands represent limited classes of antibodies that are . Careers. There are various ways a person can manage spasticity. The institution of Dr. Clardy has received personal compensation in the range of $0-$499 for serving as a Consultant for VielaBio. People who receive a diagnosis of MS typically have positive test results, indicating that OCB is present in the CSF. government site. Epub 2022 Dec 16. Address correspondence to the author at: Division of Clinical Biochemistry, Department of Laboratory Medicine, Dr. Everett Chalmers Regional Hospital, Horizon Health Network, Fredericton, New Brunswick, Canada E3B 5N5. The .gov means its official. ways to boost your brainpower. 19952023 Mayo Foundation for Medical Education and Research. Here are 12 simple and fun! The institution of Dr. Clardy has received personal compensation in the range of $0-$499 for serving as a Consultant for Genentech. None found; four or more CSF-specific bands have been shown to be most consistent with MS. My dizziness is best described by feeling drunk all the time. WebOligoclonal immunoglobulin G (IgG) bands (OCBs) are a useful diagnostic tool to detect a central humoral response. 2022;109:129-163. doi: 10.1016/bs.acc.2022.03.004. Serums and CSF samples were sent to Bioscientia International labs in Germany for extensive autoimmune, microbiological, and rheumatological markers analyses. Submissions must be < 200 words with < 5 references. Finally, in an adjusted logistic regression fit to death, there was a significant decrease in odds of death for those with matched plus unique oligoclonal bands compared to those with only matched bands (OR 0.52 [95% CI 0.29 0.94]). Discover the common causes of headaches and how to treat headache pain. Examining CSF and serum in parallel for OCBs of IgG provides more diagnostic information than examining CSF alone, and the latter is potentially misleading. More guidelines and information on Disputes & Debates, Involvement of Type I Interferon Signaling in Muscle Stem Cell Proliferation During Dermatomyositis, Neurology | Print ISSN:0028-3878 1990;27:436-443; Hortin GL: Amino Acids, Peptides, and Proteins. But it can also be used to treat disorders that cause overactive muscles or pain. Previously considered an incidental finding, some patients have matched IgG bands present in both the CSF and serum. In a cohort of 1307 patients analyzed in 2018, where 159 had demyelinating disease, the Mayo Clinic oligoclonal banding test had a clinical sensitivity of 74% and clinical specificity of 89%, with a ROC AUC of 0.813 when 2 or more unique cerebrospinal fluid bands are used as a cutoff for positive. 7th ed. 2003:120:672-675, 3. A positive test might also indicate that you have: As always, give your doctor complete information on what medications you take. The CSF oligoclonal band screen looks for these bands in your CSF. Clin Chem Lab Med. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements. and transmitted securely. Cerebrospinal fluid (CSF) and serum, collected at the same time, 0.5 mL cerebrospinal fluid (CSF) and 0.5 mL serum, Red-top tube or gel-barrier tube and plastic (CSF) tube, Plasma instead of serum specimen (since fibrinogen band may obscure the electrophoretic zone); serum and CSF not collected within eight hours of each other, Diagnose diseases of the central nervous system including meningitis, tumor, syphilis, and multiple sclerosis, Isoelectric focusing (IEF) and immunoblotting on agarose gel. 1987 Oct;44(10):1041-4 The results can help diagnose conditions of the central nervous. The presence of 2 or more unique CSF Next, theyll apply a local anesthetic. Diagnoses in the second group of patients, with unique CSF OCBs in addition to serum OCBs, resembled those among patients with CSF OCBs alone. When the oligoclonal band assay detects 2 or more unique IgG bands in the cerebrospinal fluid (CSF), the result is positive. FOIA Last medically reviewed on March 18, 2022. The results of an EEG can be used to rule out or confirm. Submitted comments are subject to editing and editor review prior to posting. Patients with matched plus unique oligoclonal bands were more likely to have an abnormal MRI spine (p<0.001) and CSF pleocytosis (p<0.001). Only patients with matched or matched plus unique oligoclonal band results were analyzed. Authors' Disclosures or Potential Conflicts of Interest:No authors declared any potential conflicts of interest. The presence of oligoclonal bands in CSF, but not serum, is indicative of local See additional information. We avoid using tertiary references. The determination of intrathecal IgM, including IgM/lipid-specific IgM OCBs, on the other hand, seems to be of prognostic relevance and is associated with a more aggressive disease course. Clinical charts were reviewed by a neuroimmunologist. OCB in CSF is detected in about 95% of MS The separated immunoglobulins (Ig) are visualized by an IgG immunoblot, and OCBs that are present in the CSF and not in the serum are reported. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Multiple Sclerosis Association of America, https://www.nationalmssociety.org/Symptoms-Diagnosis/Diagnosing-Tools/Cerebrospinal-Fluid-(CSF), https://www.frontiersin.org/articles/10.3389/fimmu.2019.00726/full, https://www.nationalmssociety.org/Symptoms-Diagnosis/Diagnosing-MS, https://www.nhs.uk/conditions/lumbar-puncture/, https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/lumbar-puncture, New clues to slow aging? Approximately 2% to 3% of clinically confirmed MS patients show little or no evidence of oligoclonal bands in the CSF; however oligoclonal bands may develop as the disease progresses. Am J Clin Pathol. 2003 Nov:120(5):672-675, 3. According to Mayo Medical Laboratories, this screen is positive in 70 to 80 percent of MS patients. Hi, Thank you for your question. It sounds that these OGBs may be due to demyelination of brain tissues. Additionally, your symptoms could be due Author Lone Frank talks about Dr. Robert Heath, who was hailed a pioneer and criticized as an exploiter during his career. Detection of oligoclonal IgG bands (OCBs) in parallel cerebrospinal fluid (CSF) and serum samples is an important tool to support the diagnosis of neuroinflammatory diseases such as multiple sclerosis (MS) ( 1 ). 1998 Jul;61(7):375-81. The presence of these immunoglobulins can indicate inflammation in the central nervous system (CNS), which can suggest that a person has multiple sclerosis (MS). OLIG - Overview: Oligoclonal Banding, Serum and Spinal Fluid Find out more about MS, including what, Relapsing-remitting multiple sclerosis (MS) is the most common type of MS. Had clear MRI's of both brain and spine in January. oligoclonal bands Fax 506-452-5422; e-mail. Andersson M, Alvarez-Cermeno J, Bernardi G, et al: Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report. For th when i was 17 i had an episode that caused the loss of use in my legs upon awakening from sleep , the episode lasted but for a brief 10 m Hi friends, This helps the doctor insert the needle more easily. OCBs can also be present in other central nervous system (CNS) disorders, including antibody-mediated, inflammatory, infectious, and neurodegenerative conditions, as well as in both chronic and early disease stages, suggesting the occurrence of primary or concomitant immune-mediated processes. The anesthetic will reduce or eliminate the pain of needle insertion. 1975 Aug;52(2):111-20 springerlink.com/content/lv0r2xt58rj600jb/, mayoclinic.org/tests-procedures/lumbar-puncture/basics/definition/prc-20012679, mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/8017, books.google.com/books?id=FCbXDdOvB9IC&pg=PA319&lpg=PA319&dq=oligoclonal+Banding+meningitis&source=bl&ots=xXaV_Bq2ej&sig=Cf3UhU2a8sxtckVKViJkIujPHPE&hl=en&sa=X&ei=b1EEUL2GC-LC2QWx4dGqCw&ved=0CEwQ6AEwAQ#v=onepage&q=oligoclonal%20Banding%20meningitis&f=false, When Forgiveness Becomes Enough: Cindy Jenkins Talks OCD. The institution of Dr. Clardy has received research support from Sumaira Foundation for NMO. I have had severe dizziness since August of 2009. What We Know, have any neurological illnesses or conditions. Diagnostics (Basel). eCollection 2017. Since 80% of normal CSF protein is derived from serum, patients with serum monoclonal proteins may also have corresponding CSF bands. Results: We identified 502 patients with matched oligoclonal bands and 117 patients with matched plus unique oligoclonal bands. WebCSF oligoclonal banding is a test to look for inflammation-related proteins in the cerebrospinal fluid (CSF).